Peptide vaccines are vaccines prepared by chemical synthesis techniques based on the amino acid sequence of a known or predicted antigenic epitope in the pathogen antigen gene.

Traditional vaccines are generally prepared in two ways: one is attenuated vaccines that can induce immunity but do not cause disease, such as yellow fever, poliomyelitis, measles vaccines or BCG vaccines; Another type is inactivated vaccines (such as pertussis bacilli, rabies virus, typhoid bacilli). Peptide vaccines, due to their complete synthesis, do not have the problem of toxicity rebound or incomplete inactivation. Especially for some microbial pathogens that cannot obtain sufficient amounts of antigens through in vitro culture.

Compared with attenuated and inactivated vaccines, viral antigen epitope peptide vaccines have the following advantages:

1) More suitable for dealing with virus mutations;

2) Can meet the requirements of fast and efficient production, and reduce the cost of vaccine production;

3) The vaccine lacks a complete viral structure and has a high level of safety.

Advantages of company peptide synthesis:

Good quality: For long and short peptides, liquid-phase peptide synthesis and solid-phase peptide synthesis processes are adopted to synthesize peptides, and HPLC is used to purify the products. The final product provides corresponding mass spectra, HPLC chromatograms for purity analysis, and COA.

Fast delivery: The ordering process is simple, the peptide synthesis production process is carried out in shifts, the delivery process is smooth, and the confirmation of payment process is convenient and fast. We can deliver the finished product for use as soon as possible, reducing intermediate links.

Confidentiality: We will strictly keep confidential the peptide synthesis sequences provided by our customers and will never disclose them.

Scope of Peptide Synthesis Services:

1. Different lengths: Polypeptides composed of up to 100 amino acids can be synthesized.

2. Different quantity specifications: mg level, g level, kg level

3. Different HPLC purities: 80%, 90%, 95%, 98%, 99%

4. Peptide synthesis test report: HPLC spectrum, Mass spectrum, COA report

If requested by the customer, we can provide the following test reports at an additional cost:

Peptide content, water content, acetic acid content, trifluoroacetic acid content, endotoxin content

5. Different modifications:

N-terminal modified peptide synthesis | Peptide customization (Ac, Fmoc, Z, Bz, etc.)

N-terminal fatty acid modified peptide synthesis | Peptide customization (such as coumarin acid, palmitic acid, stearic acid, etc.)

C-terminal modified peptide synthesis | Peptide customization (- NH2, - RNA, - AMC, - OME, - OET, etc.)

Fluorescence modified peptide synthesis | Peptide customization (FITC, Biotin, 5-Fam, Rhodamine, etc. are modified at the N-terminus, middle of the peptide chain, and C-terminus of the peptide)

Phosphorylation modified peptide synthesis | Peptide customization (Thr (HPO3), Tyr (HPO3), Ser (HPO3), etc.)

Methylation modified peptide synthesis | Peptide customization (Lys (Me), Lys (Me), Lys (Me), Arg (Me), etc.)

Synthesis of special amino acid peptides | Peptide customization (D-type amino acids, beta amino acids, homo amino acids, non natural amino acids, various side chain modified amino acids)

Peptide KLH, BSA, OVA coupling services (via Cys coupling or carboxy terminal coupling of KLH, BSA, OVA)

6. Different peptide structures:

Linear peptide

Branched peptide lysine branched peptide

Lys two branched peptide, Lys four branched peptide, Lys eight branched peptide

Ornithine branched peptide

Orn two branched peptide, Orn four branched peptide, Orn eight branched peptide

Asymmetric branched peptide lysine asymmetric bifurcated peptide

Asymmetric branched peptide of ornithine

Glutamic acid side chain peptide

Aspartate side chain peptide

A polypeptide that forms a ring through disulfide bonds

Single disulfide peptide, disulfide peptide, triple disulfide peptide,

Molecular Symmetric Disulfide Peptide, Molecular Asymmetric Disulfide Peptide)

Polypeptides that form rings through amide bonds

Peptides with cyclic amide bonds at the beginning and end, and peptides with cyclic amide side chains

7. Different scales:

Single peptide

Batch peptide

Peptide library (overlapping peptide library, amino acid screening peptide library, targeted screening peptide library, random peptide library (chaotic peptide library),

Truncated peptide library, single site scanning peptide library, dual site combination scanning peptide library, triple site combination scanning peptide library

Dipeptide Combination Peptide Library Tripeptide Combination Peptide Library

8. Packaging: Peptides can be packaged according to customer requirements (free packaging of up to 10 tubes per peptide).